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novel single-sensor multiplexed marker assay – a step towards simplified disease management and detection? Author:Natalie Harrison, Future Science Group Researchers from the Biodesign Institute at ArizonaState University (ASU), USA engineer a sensor capable of simultaneously measuring multiple analytes in a label-free and rapid manner The group, led by Dr Jeffrey La Belle, Assistant Research Professor at ASU, were able to measure the interaction between ultralow levels of analyte (the typical inflammatory markers, interleukin-12 and TNF-α) and molecular recognition elements by electrochemical impedance spectroscopy and quantification. Asked why this work is so important, La Belle stipulated that for many diseases, relying http://lipitorgeneric-online247.com/ on a single biomarker is inefficient and not always most accurate, highlighting prostate specific antigen (PSA) for prostate cancer and glucose monitoring for diabetes as examples. http://lipitorgeneric-online247.com/lopid-cholesterol-meds.html Elaborating on PSA: “The clinical community acknowledges it is a viable marker, but many results still need cross confirmation from a digital rectal exam (DRE) to be accurate or sensitive enough to diagnose cancer“. In the case lipitor dosage of diabetes, for the past 30 years, glucose has remained the only monitored biomarker. In addition to noncompliance when it comes to self-monitoring blood glucose, quarterly tests like glycosylated hemoglobin, HbA1c, are only adhered to, on average, once a year. “This noncompliance has led to direct and indirect costs of diabetes generating an estimated $500 billion a year in additional costs to US health care, which is not sustainable and needs to be lowered- this is up from $300 billion in 2009 and $174 billion in 2007. A better test, providing more metabolic, immunological and inflammation type data could help,” remarked La Belle. The ASU professor assigned the task of putting all the targets on the same sensor, as well as the sheer novelty of the work, as the ceftin biggest hurdles his team have faced. He continued: “instrumentation, that’s another issue- we needed biologists, endocrinologists, engineers – electrical, computer, biomedical, and that’s just to figure this all out. Luckily at ASU, we have a great student population to draw from and support from the School of Biological and Health Systems Engineering’s Biomedical Engineering program”. The next steps for the researchers will involve developing or adapting models to understand, why, electrochemically, this technique works and makes sense. As La Belle points out: “data is one thing, complete understanding is another”. There remains a lot of work to be done in the field of identifying markers for particular diseases; especially in animal studies. La Belle speculates: “sometimes when you determine one frequency of one biomarker and then look at another biomarker of interest, both can be very close to one another and therefore are hard to differentiate”, as was the case for the inflammatory markers, which demonstrated considerable overlap (Figures 1 & 2). “Hence our tuning could be used to move one frequency away from the other and

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put all biomarker recognition elements onto a single device” (Figure 3). He went on to speculate that development of instrumentation and signal processing, currently under development, are now required (Figure 4). With the ability to multiplex targets and still use an assay that takes under 90 seconds per sample, the wider implications of this work extend all the way to high-throughput screening. Concluding with the question of future technological developments, La Belle remarked: “we are starting to partner with collaborators at ASU and in industry to obtain the right instrumentation for the studies. We are also collaborating with the Mayo Clinic in Scottsdale to have clinical experts and studies to be preformed when we are ready for that stage, we are still early on”. Source: La Belle J, Demirok U, Patel D, Cook C. Development of a novel single sensor multiplexed marker assay. Analyst, 2011, 136, 1496-1501

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